Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Brief Communication
Case Report
Case Series
Current Issue
Editorial
Editorial Note
FOREWORD
From the Editor's Desk
Letter to Editor
Letter to the Editor
Original Article
Original Research
Photoessay
Pictorial Review
Review Article
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Brief Communication
Case Report
Case Series
Current Issue
Editorial
Editorial Note
FOREWORD
From the Editor's Desk
Letter to Editor
Letter to the Editor
Original Article
Original Research
Photoessay
Pictorial Review
Review Article
View/Download PDF

Translate this page into:

Letter to the Editor
ARTICLE IN PRESS
doi:
10.25259/FH_50_2024

Rare case of isolated optic neuritis due to systemic lupus erythematosus (SLE)

Associate Professor, Department of Neurology, All India Institute of Medial Sciences Bhopal, Bhopal, Madhya Pradesh, India
Senior Resident, Department of Neurology, All India Institute of Medial Sciences Bhopal, Bhopal, Madhya Pradesh, India

* Corresponding author: Dr. Priyanka V Kashyap, Associate Professor, Department of Neurology, All India Institute of Medial Sciences Bhopal, Bhopal, Madhya Pradesh, India. priyanka.tem@aiimsbhopal.edu.in

Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Kashyap VP, Bhat MK, Rare case of isolated optic neuritis due to systemic lupus erythematosus (SLE). Future Health. doi: 10.25259/FH_50_2024

Dear Editor,

We want to share a unique clinical presentation observed in our practice that highlights the importance of a detailed evaluation of the wide spectrum of causes leading to optic neuritis. In this case, SLE presented as an isolated optic neuritis (ON).

ON is characterized by inflammation of the optic nerve, causing varying degrees of vision loss. The mechanisms underlying optic neuritis are diverse and can include either demyelinating or axonal damage due to infections, immune-related conditions, toxins, or paraneoplastic disorders1. Neuro-ophthalmic manifestations of SLE are rare, with a prevalence of 3.6%2, and only 1% of patients have optic nerve or optic chasmal involvement3,4. Optic neuritis described in lupus patients can present as acute or progressive, painless or painful vision loss, depending on the location of the pathology. The etiology of optic nerve involvement varies from demyelination to vaso-occlusive disease and axonal necrosis. We encountered a 48-year-old female patient presenting with a history of subacute onset, progressive, painless visual loss over the past year without any history suggestive of infective, toxic, or immune-related illnesses. The patient’s vision was severely impaired, which was reduced to hand movements and counting fingers at a distance of 1 foot. Ophthalmological examination revealed bilateral optic disc pallor, indicative of optic atrophy, and bilateral pupillary responses were sluggish. The rest of the neurological examination was noncontributory.

MRI revealed attenuation of retrobulbar segments of bilateral optic nerves with altered signal intensity over an approximate 1.3 cm long segment. VEP demonstrated bilateral prolonged P100 latency, with 127 ms in the right and 126 ms in the left eye. The patient tested positive for anti-nuclear antibody (ANA) by the immune-fixation (IF) method, showing a speckled pattern with a titer of 1:200. The serum neuromyelitis optica-myelin oligoclonal glycoprotein (NMO-MOG) panel was negative. Oligoclonal bands (OCBs) were positive in both serum and CSF, indicating a systemic autoimmune disease process.

Anti-Smith antibody levels measured by enzyme-linked immunosorbent assay (ELISA) were positive with a value of 40.79 (>20 being positive), showing a specificity of 96–98% for SLE. Additional investigations revealed low C4 and normal C3 levels. The retinal nerve fiber layer (RNFL) of the optic nerve was also thinned. Thus, these findings confirm the diagnosis of bilateral optic neuritis secondary to SLE, presenting as an isolated syndrome.

SLE-related ON follows a different course and requires distinct management compared to idiopathic or other autoimmune-related ON5. The prognosis and visual outcomes in SLE-related ON are directly influenced by specific and prolonged treatment compared to primary demyelinating insult. Timely identification of the disease and early treatment are crucial for achieving better visual outcomes and improving prognosis.

This case highlights the importance of considering vasculitis as a differential diagnosis for bilateral painless visual loss apart from demyelinating causes. A thorough vasculitis workup should be a mandatory part of the diagnostic process. Timely administration of appropriate immunosuppressive drugs can help prevent further damage and potentially aid in the recovery of vision loss.

Ethical approval

Institutional Review Board approval is not required.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

Use of artificial intelligence (AI)-assisted technology for manuscript preparation

The authors confirm that there was no use of AI-assisted technology for assisting in the writing of the manuscript and no images were manipulated using AI.

References

  1. . Optic neuritis. Continuum (Minneap Minn). 2019;25:1236-64.
    [CrossRef] [PubMed] [PubMed Central] [Google Scholar]
  2. , , , , , , et al. Incidence and prevalence of major central nervous system involvement in systemic lupus erythematosus: A 3-year prospective study of 370 patients. PLoS One. 2013;8:e55843.
    [CrossRef] [PubMed] [PubMed Central] [Google Scholar]
  3. , , . Ocular manifestations of systemic lupus erythematosus: A review of the literature. Autoimmune Dis. 2012;2012:2012.
    [CrossRef] [Google Scholar]
  4. , . Acute lupus erythematosus, with fundus lesions. Proc R Soc Med. 1933;27:153-7.
    [CrossRef] [PubMed] [PubMed Central] [Google Scholar]
  5. , . Atypical optic neuritis as an initial manifestation of systemic lupus erythematosus: A case report. Available from: https://perpustakaanrsmcicendo.com/wp-content/uploads/2023/07/L110.pdf [Accessed 4 July 2024].
    [Google Scholar]

Fulltext Views
110

PDF downloads
63
View/Download PDF
Download Citations
BibTeX
RIS
Show Sections